GABA neurotransmission and neural cation-chloride co-transporters: actions beyond ion transport.

@article{Medina2006GABANA,
  title={GABA neurotransmission and neural cation-chloride co-transporters: actions beyond ion transport.},
  author={Igor Medina and Ilona Chudotvorova},
  journal={Critical reviews in neurobiology},
  year={2006},
  volume={18 1-2},
  pages={105-12}
}
During neuronal development, gamma-aminobutyric acid (GABA), which is the principal inhibitory neurotransmitter in the mature brain, exerts a paradoxical depolarizing action that plays an important role in the generation of neuronal synaptic activities in the immature cortical structures and in the formation of the neuronal network. The depolarizing action of GABA is due to a differential organization of the chloride homeostasis system; in immature neurons it maintains an elevated intracellular… CONTINUE READING

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