GABA-mimetic actions of Withania somnifera on substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice.

@article{Yin2013GABAmimeticAO,
  title={GABA-mimetic actions of Withania somnifera on substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice.},
  author={Hua Yin and Dong Hyu Cho and Soo Joung Park and Seong Kyu Han},
  journal={The American journal of Chinese medicine},
  year={2013},
  volume={41 5},
  pages={1043-51}
}
The plant Withania somnifera (WS), also known as Ashwagandha, has been used widely in traditional medicine systems in India and Nepal (Ayurveda), and has been accepted to cure various ailments. In this study, the whole-cell patch clamp technique was performed to examine the mechanism of action of WS on the SG neurons of the Vc from mouse brainstem slices. In whole-cell patch clamp mode, methanol extract of Withania somnifera (mWS) induced short-lived and repeatable inward currents in all SG… CONTINUE READING
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