GABA-mediated neurotransmission in the ventrolateral NTS plays a role in respiratory regulation in the rat.

@article{Wasserman2002GABAmediatedNI,
  title={GABA-mediated neurotransmission in the ventrolateral NTS plays a role in respiratory regulation in the rat.},
  author={Adam M. Wasserman and Manuel Ferreira and Niaz Sahibzada and Yvonne M. Hernandez and Richard A. Gillis},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2002},
  volume={283 6},
  pages={
          R1423-41
        }
}
Our purpose was to determine whether endogenously released GABA in the ventrolateral nucleus of the solitary tract (vlNTS) of the rat influences respiration. Experiments were carried out in anesthetized, vagotomized and spontaneously breathing rats, and diaphragm electromyogram activity was measured while drugs affecting GABAergic neurotransmission were microinjected into the vlNTS and medial NTS (mNTS). Bilateral microinjection of nipecotic acid, 5 or 25 nmol, into the vlNTS (but not in the… 
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References

SHOWING 1-10 OF 56 REFERENCES
GABAergic mechanisms in nucleus tractus solitarius alter blood pressure and vasopressin release
Role of GABA within the nucleus tractus solitarii in the hypoxic ventilatory decline of awake rats.
TLDR
The results suggest that the GABA in the NTS has a pivotal role in the HVD and that this mechanism is not activated without chemoreceptor stimulation.
Specific subnuclei of the nucleus tractus solitarius play a role in determining the duration of inspiration in the rat
Effects of GABAB receptor agonists and antagonists on the bulbar respiratory network in cat
Modulation of gastric and arterial pressure by nucleus tractus solitarius in rat.
TLDR
It is suggested that local stimulation of neurons in a specific region of the NTS elicits vagally mediated alterations of tonic GP and phasic activity and that AP and GP can be influenced independently in the medial NTS region.
Is L-glutamate a neurotransmitter of baroreceptor information in the nucleus of the tractus solitarius?
  • C. Leone, F. Gordon
  • Biology
    The Journal of pharmacology and experimental therapeutics
  • 1989
TLDR
Blockage of EAA receptors in the NTS is sufficient to abolish synaptically mediated aortic baroreflexes and observations suggest that an EAA or EAA analog other than L-glutamate may be the neurotransmitter of baroreceptor information in the rat NTS.
Influence of GABA in the nucleus of the solitary tract on blood pressure in baroreceptor-denervated rats.
TLDR
The results suggest that the lack of a tonic role of the NTS in the regulation of blood pressure in chronic SAD rats is a result of maximal GABA-mediated inhibition of relevant NTS neurons.
Electrophysiological study of dorsal respiratory neurons in the medulla oblongata of the rat
Brainstem nicotinic receptor subtypes that influence intragastric and arterial blood pressures.
TLDR
The data indicate that nicotine-induced changes in IGP result from nicotine acting at two sites, the DMV and mNTS; and that at least three different nicotinic receptors in the dorsal medulla oblongata can influence gastrointestinal and cardiovascular function.
Enhanced gamma-aminobutyric acid-B receptor agonist responses and mRNA within the nucleus of the solitary tract in hypertension.
TLDR
Chronic hypertension is associated with an upregulation of GABAB receptor function; however, the tonic activity of the system does not appear to be different between normotensive and hypertensive rats.
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