GABA induces proliferation of immature cerebellar granule cells grown in vitro.

@article{Fiszman1999GABAIP,
  title={GABA induces proliferation of immature cerebellar granule cells grown in vitro.},
  author={M{\'o}nica L. Fiszman and Laura N Borodinsky and Joseph H Neale},
  journal={Brain research. Developmental brain research},
  year={1999},
  volume={115 1},
  pages={1-8}
}
The presence of GABA and its receptors early in rodent nervous system development has lead to speculation on the role of this transmitter system in neuroblast proliferation, migration and differentiation. We studied the effect of GABA and GABA agonists on immature cerebellar granule cell proliferation and survival. Cerebellar granule cell suspensions were obtained from 6-8-day-old rats and grown in culture for up to 7 days in serum-containing or serum-free medium. The addition of GABA (0.1-100… CONTINUE READING

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