GABA-ergic effects of harmane independent of its action on benzodiazepine receptors


Among the many "endogenous ligands of benzodiazepine receptors ~' 8-carbolines [7] and, in particular, harmane [ii] and norharmane [5], exhibit the highest activity as substances competitively inhibiting specific binding of labeled benzodiazepine tranquilizers (BDT) by brain membranes. In this way the pharmacologic effects of harmanes can be regarded as the… (More)
DOI: 10.1007/BF00808195