• Psychology, Medicine
  • Published in Nature Neuroscience 2007
  • DOI:10.1038/nn2001

GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI

@article{Northoff2007GABACI,
  title={GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI},
  author={Georg Northoff and Martin Walter and Rolf F. Schulte and Johannes Beck and Ulrike Dydak and Anke Henning and Heinz Boeker and Simone Grimm and Peter Boesiger},
  journal={Nature Neuroscience},
  year={2007},
  volume={10},
  pages={1515-1517}
}
The human anterior cingulate cortex (ACC) is part of the default-mode network that shows predominant negative blood oxygen level–dependent (BOLD) responses in functional magnetic resonance imaging (fMRI). We combined fMRI during emotional processing and resting-state magnetic resonance spectroscopy measurements and observed that the concentration of GABA in the ACC specifically correlated with the amount of negative BOLD responses in the very same region. Our findings show that default-mode… CONTINUE READING

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