GABA concentration is reduced in visual cortex in schizophrenia and correlates with orientation-specific surround suppression.

@article{Yoon2010GABACI,
  title={GABA concentration is reduced in visual cortex in schizophrenia and correlates with orientation-specific surround suppression.},
  author={Jong H. Yoon and Richard J. Maddock and Ariel S. Rokem and Michael A. Silver and Michael J. Minzenberg and John Daniel Ragland and Cameron S. Carter},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 10},
  pages={3777-81}
}
The neural mechanisms underlying cognitive deficits in schizophrenia remain essentially unknown. The GABA hypothesis proposes that reduced neuronal GABA concentration and neurotransmission results in cognitive impairments in schizophrenia. However, few in vivo studies have directly examined this hypothesis. We used magnetic resonance spectroscopy (MRS) at high field to measure visual cortical GABA levels in 13 subjects with schizophrenia and 13 demographically matched healthy control subjects… CONTINUE READING
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