GABA-based therapeutic approaches: GABAA receptor subtype functions.

  title={GABA-based therapeutic approaches: GABAA receptor subtype functions.},
  author={Uwe Rudolph and Hanns M{\"o}hler},
  journal={Current opinion in pharmacology},
  volume={6 1},
It is increasingly being appreciated that GABAA receptor subtypes, through their specific regional, cellular and subcellular localization, are linked to distinct neuronal circuits and consequently serve distinct functions. GABAA receptor subtype-selective drugs are therefore expected to provide novel pharmacological profiles. Receptors containing the alpha1 subunit mediate sedation and serve as targets for sedative hypnotics. Agonists selective for alpha2- and/or alpha3-containing GABAA… CONTINUE READING
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