GABA and the behavioral effects of anxiolytic drugs.

@article{Sanger1985GABAAT,
  title={GABA and the behavioral effects of anxiolytic drugs.},
  author={D. Sanger},
  journal={Life sciences},
  year={1985},
  volume={36 16},
  pages={
          1503-13
        }
}
  • D. Sanger
  • Published 1985
  • Biology, Medicine
  • Life sciences
Much recent research has shown that benzodiazepine binding sites in the central nervous system are associated with GABA receptors. It is therefore possible that the pharmacological and therapeutic effects of benzodiazepines and drugs with similar profiles are mediated through GABAergic mechanisms. In this paper the evidence is considered for a possible involvement of GABA in the behavioral effects of anxiolytic drugs. There are a number of reports that the behavioral actions of anxiolytics can… Expand
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It is concluded that GABAb receptors probably mediate this effect of baclofen and that such receptors may be a potential site of anxiolytic drug action. Expand
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existing data are sufficient to justify the prediction that GABAergic agents, in the near future, will be much used in the field of behavioral pharmacology, and it is hoped that the present review will contribute to this. Expand
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TLDR
It is proposed that GABAA and GABAB receptors differ not only at the cellular level, but that they also have different functions in the mammalian central nervous system. Expand
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TLDR
GA can modulate the responsiveness of this BZ binding site since the addition of GABA to cortical membranes in vitro results in an increased affinity of the 3H-diazepam binding site for its ligand. Expand
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This work has reported the presence of a high affinity, saturable, stereospecific binding site for benzodiazepines in synaptic membrane preparations obtained from brain of different animal species, including man, and this high affinity binding is now used to determine the therapeutic potency and to study the mode of action of Benzodiazepine in anxiety. Expand
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Abstract The role of γ-aminobutyric acid (GABA) in the actions of ben-zodiazepines is considered from a behavioral pharmacology perspective. Much research indicates that GABA mediates variousExpand
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TLDR
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Although the BZs did not alter the spontaneous firing rate of the DR, both the systemic and iontophoretic administration of these drugs were found to potentiate the inhibitory response produced by GABA, suggesting that this potentiation is mediated postsynaptically. Expand
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The demonstration of anxiolytic activity by the GABAmimetic drug, valproic acid, suggests that GABA mechanisms may mediate the anxioleytic action of benzodiazepines. Expand
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