GABA and nitric oxide in the PVN are involved in arterial pressure control but not in the chemoreflex responses in rats.

@article{Cruz2009GABAAN,
  title={GABA and nitric oxide in the PVN are involved in arterial pressure control but not in the chemoreflex responses in rats.},
  author={Josiane de Campos Cruz and Benedito H Machado},
  journal={Autonomic neuroscience : basic & clinical},
  year={2009},
  volume={146 1-2},
  pages={47-55}
}
GABAergic, nitrergic and glutamatergic mechanisms in the PVN on the baseline mean arterial pressure (MAP), heart rate (HR) and on the cardiovascular responses to chemoreflex activation in awake rat were evaluated. Chemoreflex was activated with KCN before and after microinjections into the PVN. Bicuculline into the PVN increased baseline MAP (94+/-3 vs 113+/-5 mmHg) and HR (350+/-9 vs 439+/-18 bpm) but had no effect on the pressor (49+/-5 vs 47+/-6 mmHg) or bradicardic (-213+/-23 vs -256+/-42… CONTINUE READING