GABA and neuroligin signaling: linking synaptic activity and adhesion in inhibitory synapse development

@article{Huang2008GABAAN,
  title={GABA and neuroligin signaling: linking synaptic activity and adhesion in inhibitory synapse development},
  author={Z. Josh Huang and Peter Scheiffele},
  journal={Current Opinion in Neurobiology},
  year={2008},
  volume={18},
  pages={77-83}
}
GABA-mediated synaptic inhibition is crucial in neural circuit operations. In mammalian brains, the development of inhibitory synapses and innervation patterns is often a prolonged postnatal process, regulated by neural activity. Emerging evidence indicates that gamma-aminobutyric acid (GABA) acts beyond inhibitory transmission and regulates inhibitory synapse development. Indeed, GABA(A) receptors not only function as chloride channels that regulate membrane voltage and conductance but also… CONTINUE READING

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