GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis

@article{Loturco1995GABAAG,
  title={GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis},
  author={Joseph J. Loturco and David F. Owens and Mark J.S. Heath and Marion B. E. Davis and Arnold R. Kriegstein},
  journal={Neuron},
  year={1995},
  volume={15},
  pages={1287-1298}
}
We have found that, during the early stages of cortical neurogenesis, both GABA and glutamate depolarize cells in the ventricular zone of rat embryonic neocortex. In the ventricular zone, glutamate acts on AMPA/kainate receptors, while GABA acts on GABAA receptors. GABA induces an inward current at resting membrane potentials, presumably owing to a high intracellular Cl- concentration maintained by furosemide-sensitive Cl- transport. GABA and glutamate also produce increases in intracellular… Expand
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