GABA alters the metabolic fate of [U-13C]glutamate in cultured cortical astrocytes.

  title={GABA alters the metabolic fate of [U-13C]glutamate in cultured cortical astrocytes.},
  author={Mary C McKenna and Ursula Sonnewald},
  journal={Journal of neuroscience research},
  volume={79 1-2},
The effect of gamma-aminobutyric acid (GABA) on glutamate metabolism was studied by (13)C-nuclear magnetic resonance (NMR) spectroscopy. Cerebral cortical astrocytes were incubated with 0.5 mM [U-(13)C]glutamate and 5 mM glucose in the presence or absence of 0.2 mM GABA for 2 hr. (13)C-labeled glutamate, glutamine, and aspartate were observed in cell extracts, and (13)C-labeled glutamine and lactate were present in the media. Both uniformly labeled glutamate and [1,2,3-(13)C]glutamate derived… CONTINUE READING


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