GABA agonists and potential antagonists related to muscimol

@article{Arnt1979GABAAA,
  title={GABA agonists and potential antagonists related to muscimol},
  author={J. Arnt and P. Krogsgaard‐Larsen},
  journal={Brain Research},
  year={1979},
  volume={177},
  pages={395-400}
}
  • J. Arnt, P. Krogsgaard‐Larsen
  • Published 1979
  • Biology, Medicine
  • Brain Research
  • A variety of 3-isoxazolol zwitterions related to muscimol have been developed and tested as GABA agonists 2,11A3-15,22. In general, minor structural modifications of the muscimol molecule result in dramatic loss of affinity for the GABA receptorsll,la, 15. However, like muscimol s,15 dihydromuscimol (5-aminomethyl-2isoxazolin-3-ol) la,17 and THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) 7 are potent GABA agonists, which are pharmacologically active after systematic or intracerebral… CONTINUE READING
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