GABA action in immature neocortical neurons directly depends on the availability of ketone bodies.

@article{Rheims2009GABAAI,
  title={GABA action in immature neocortical neurons directly depends on the availability of ketone bodies.},
  author={Sylvain Rheims and Carl D Holmgren and Gen{\`e}vieve Chazal and Jan Mulder and Tibor Harkany and Tanya Zilberter and Yuri Zilberter},
  journal={Journal of neurochemistry},
  year={2009},
  volume={110 4},
  pages={1330-8}
}
In the early postnatal period, energy metabolism in the suckling rodent brain relies to a large extent on metabolic pathways alternate to glucose such as the utilization of ketone bodies (KBs). However, how KBs affect neuronal excitability is not known. Using recordings of single NMDA and GABA-activated channels in neocortical pyramidal cells we studied the effects of KBs on the resting membrane potential (E(m)) and reversal potential of GABA-induced anionic currents (E(GABA)), respectively. We… CONTINUE READING
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