GABA Pharmacology: The Search for Analgesics

  title={GABA Pharmacology: The Search for Analgesics},
  author={Kenneth E. McCarson and Sam J Enna},
  journal={Neurochemical Research},
Decades of research have been devoted to defining the role of GABAergic transmission in nociceptive processing. Much of this work was performed using rigid, orthosteric GABA analogs created by Povl Krogsgaard-Larsen and his associates. A relationship between GABA and pain is suggested by the anatomical distribution of GABA receptors and the ability of some GABA agonists to alter nociceptive responsiveness. Outlined in this report are data supporting this proposition, with particular emphasis on… CONTINUE READING

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Diversity in structure, pharmacology, and regulation of GABAA receptors. In: Enna SJ, Bowery NG (eds) The GABA receptors

HBJ Mohler, B Benson, B Luscher, U Rudolph, JM Fritschy
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