GABA Outside the CNS

  title={GABA Outside the CNS},
  author={S{\'a}ndor L. Erdő},
  booktitle={Springer Berlin Heidelberg},
  • S. Erdő
  • Published in Springer Berlin Heidelberg 1992
  • Biology
GABA in the Peripheral Nervous System.- The Role of GABA in the Peripheral Nervous System.- GABAergic Neurons in the Myenteric Plexus.- GABA and Gut Motility.- The GABAergic Innervation of Paravertebral Sympathetic Ganglia.- L-Glutamate Decarboxylase Immunoreactivity in the Sympathoadrenal System.- GABAergic Action on Cholinergic Axon Terminals in the Superior Cervical Ganglion.- GABA in Non-Neural Tissues.- Non-Neuronal GABA Systems: An Overview.- GABA and Endocrine Cells of the Gastro-entero… 
Modulation by GABA of neuroplasticity in the central and peripheral nervous system
Evidence is available that GABA via A- and/or B-receptors may exert direct trophic actions and the regulation of both types of trophics actions (direct, receptor-mediated vs. indirect, bioelectric activity dependent) is discussed.
Expected Therapeutic Use of GABA Agonists and Antagonists for Gut Motility Disorders
The criteria required to establish GABA as a neurotransmitter have been fulfilled and the criteria required for GABA's removal from the synaptic cleft and conserved for reuse are fulfilled.
Differential expression of γ-aminobutyric acid receptor A (GABAA) and effects of homocysteine
Examining the expression of GABAA receptor and its subunits in non-neural tissue enlarge knowledge on distribution of GABA receptors and give novel ideas of the effects of Hcy on different organs is given.
Pharmacology of Mammalian GABAB Receptors
This chapter summarizes the pharmacological properties of the GABAB receptor(s), making reference to its potential significance as a therapeutic target.


GABA may be a neurotransmitter in the vertebrate peripheral nervous system
Evidence is presented that GABA may also be a neurotransmitter in the vertebrate peripheral autonomie nervous system and levels of endogenous GABA in strips of taenia coli containing the myenteric plexus are measured.
GABA immunoreactivity and 3H-GABA uptake in mucosal epithelial cells of the rat stomach.
It was found that although GABA immunoreactive nerve fibres are essentially absent from this site, some mucosal cells are strongly GABA-immunoreactive, and autoradiographic experiments provide evidence that these cells also possess high-affinity GABA uptake sites.
GABA neuron systems in hypothalamus and the pituitary gland. Immunohistochemical demonstration using antibodies against glutamate decarboxylase.
The distribution of gamma-aminobutyric acid nerve fibers and cell bodies in the rat hypothalamus and pituitary gland was immunohistochemically examined and provided a morphological basis by which GABA of hypothalamic origin may regulate the neuroendocrine system.
Immunohistochemical demonstration of GABAergic neurons in the enteric nervous system
Results add a definitive support to the previous suggestion that GABA serves as an autonomic neurotransmitter in vertebrates and determine the functional role of GABAergic neurons within the complex neuronal circuitry that controls gut functions.
GABA affects the release of gastrin and somatostatin from rat antral mucosa
The effects of GABA on gastrin and somatostatin release from isolated rat antral mucosa in short-term in vitro incubations are reported here.
Immunohistochemical studies of the GABA system in the pancreas.
Results provide morphological evidence of the coexistence of GABA and insulin in the beta-cells of the endocrine pancreas in rats treated with streptozotocin or alloxan.
Intrinsic gamma aminobutyric acid receptors modulate the release of catecholamine from canine adrenal gland in situ.
It is shown that GABA modulates the spontaneous release of catecholamines and the release elicited by electrical stimulation of the splanchnic nerve, and denervation of the adrenal glands failed to prevent the THIP-elicited release ofcatecholamine.
Epilepsy and gamma-aminobutyric acid-mediated inhibition.