GABA Neurons of the VTA Drive Conditioned Place Aversion

  title={GABA Neurons of the VTA Drive Conditioned Place Aversion},
  author={Kelly R. Tan and C{\'e}dric Yvon and Marc Turiault and Julie J. Mirzabekov and Jana Doehner and Gwena{\"e}l Labou{\`e}be and Karl Deisseroth and Kay M Tye and Christian L{\"u}scher},
Salient but aversive stimuli inhibit the majority of dopamine (DA) neurons in the ventral tegmental area (VTA) and cause conditioned place aversion (CPA). The cellular mechanism underlying DA neuron inhibition has not been investigated and the causal link to behavior remains elusive. Here, we show that GABA neurons of the VTA inhibit DA neurons through neurotransmission at GABA(A) receptors. We also observe that GABA neurons increase their firing in response to a footshock and provide evidence… CONTINUE READING
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