GABA Itself Promotes the Developmental Switch of Neuronal GABAergic Responses from Excitation to Inhibition

  title={GABA Itself Promotes the Developmental Switch of Neuronal GABAergic Responses from Excitation to Inhibition},
  author={K. Ganguly and A. F. Schinder and S. Wong and M. Poo},
  • K. Ganguly, A. F. Schinder, +1 author M. Poo
  • Published 2001
  • Biology, Medicine
  • Cell
  • GABA is the main inhibitory neurotransmitter in the adult brain. Early in development, however, GABAergic synaptic transmission is excitatory and can exert widespread trophic effects. During the postnatal period, GABAergic responses undergo a switch from being excitatory to inhibitory. Here, we show that the switch is delayed by chronic blockade of GABA(A) receptors, and accelerated by increased GABA(A) receptor activation. In contrast, blockade of glutamatergic transmission or action… CONTINUE READING
    639 Citations

    Figures and Topics from this paper

    Activity-mediated shift in reversal potential of GABA-ergic synaptic currents in immature neurons.
    • 20
    Trophic actions of GABA on neuronal development
    • 385
    • PDF
    Excitatory actions of gaba during development: the nature of the nurture
    • Y. Ben-Ari
    • Biology, Medicine
    • Nature Reviews Neuroscience
    • 2002
    • 2,031
    • PDF
    GABAergic signaling in the developing cerebellum
    • 23
    • PDF
    Maturation of the GABAergic Transmission in Normal and Pathologic Motoneurons
    • 23
    • PDF
    Is there more to gaba than synaptic inhibition?
    • 1,005
    Instructions for use Title GABAergic signaling in the developing cerebellum
    • PDF


    GABA: an excitatory transmitter in early postnatal life
    • 1,058
    Glutamate Inhibits GABA Excitatory Activity in Developing Neurons
    • 67
    • PDF
    Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors
    • 793
    GABA neurotransmission in the hypothalamus: developmental reversal from Ca2+ elevating to depressing
    • 259
    • PDF
    GABAA receptor stimulation promotes survival of embryonic rat striatal neurons in culture.
    • 63
    The K+/Cl− co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
    • 1,850
    • Highly Influential