GABA Itself Promotes the Developmental Switch of Neuronal GABAergic Responses from Excitation to Inhibition

@article{Ganguly2001GABAIP,
  title={GABA Itself Promotes the Developmental Switch of Neuronal GABAergic Responses from Excitation to Inhibition},
  author={K. Ganguly and A. F. Schinder and S. Wong and M. Poo},
  journal={Cell},
  year={2001},
  volume={105},
  pages={521-532}
}
  • K. Ganguly, A. F. Schinder, +1 author M. Poo
  • Published 2001
  • Biology, Medicine
  • Cell
  • GABA is the main inhibitory neurotransmitter in the adult brain. Early in development, however, GABAergic synaptic transmission is excitatory and can exert widespread trophic effects. During the postnatal period, GABAergic responses undergo a switch from being excitatory to inhibitory. Here, we show that the switch is delayed by chronic blockade of GABA(A) receptors, and accelerated by increased GABA(A) receptor activation. In contrast, blockade of glutamatergic transmission or action… CONTINUE READING
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