GABA Heteroreceptors Modulate Noradrenaline Release in Human Dental Pulp

@article{Parker2013GABAHM,
  title={GABA Heteroreceptors Modulate Noradrenaline Release in Human Dental Pulp},
  author={D. A. Parker and V. Marino},
  journal={Journal of Dental Research},
  year={2013},
  volume={92},
  pages={1017 - 1021}
}
γ-aminobutyric-acid-containing neurons and GABAB receptors have been identified in human dental pulp; however, their significance in pulpal physiology is unclear. The purpose of this study was to determine whether pre-synaptic GABAergic heteroreceptors influence the release of noradrenaline (NA). Segments of vital pulp were incubated in [3H]NA (0.6 μM) and superfused with Krebs solution. GABA, a GABAB receptor agonist (baclofen), GABAA and B receptor antagonists [bicuculline and (+)-(S)-5, 5… Expand
Human presynaptic receptors.
TLDR
This review will focus on presynaptic receptors in human tissues and the activation of inhibitory α2-adrenoceptors on postganglionic parasympathetic neurons. Expand
FGF2-responsive genes in human dental pulp cells assessed using a rat spinal cord injury model
TLDR
Insight is provided into the role of FGF2-responsive genes, especially GABRB1, in recovery from SCI, using hDPCs treated with FGF3, which are identified via gene expression analyses in these lines. Expand
The influence of plasticization on the process of dissolution of polyarylate F-1 and polysulfone in some solvents: The role of lyophilic additives
The influence of a small amount of a polar liquid introduced into a solvent on the solubility of a polymer in the solvent was studied. As exemplified by the polyarylate F-1-dioxane system, theExpand

References

SHOWING 1-10 OF 29 REFERENCES
Presynaptic control of noradrenaline release from sympathetic nerves in human dental pulp.
TLDR
It is concluded that the sympathetic nerves in human dental pulp possess inhibitory presynaptic alpha 2-adrenoceptors and dopamine receptors. Expand
Modulation by presynaptic β-adrenoceptors of noradrenaline release from sympathetic nerves in human dental pulp
TLDR
The results establish the presence of presynaptic β -adrenoceptors on sympathetic nerves in human dental pulp and it is suggested that they are of the β 2 -subtype, although a greater range of agonists and antagonists needs to be used to clarify the nature of theβ -ad Renoceptor subtype. Expand
Evidence for presynaptic cholinergic receptors in sympathetic nerves in human dental pulp.
TLDR
It was concluded that sympathetic nerves in human dental pulp possess (a) presynaptic muscarinic receptors that inhibit the SI release of noradrenaline, and (b) nicotinic receptors that evoke the release of Noradrenalin and that inhibits theSI release of the transmitter. Expand
Evaluation of functional GABA(B) receptors in dental pulp.
TLDR
The presence of GABA and its receptor, GABA(B), suggests that this system may be relevant in the production or management of endodontic pain. Expand
Modulation by presynaptic beta-adrenoceptors of noradrenaline release from sympathetic nerves in human dental pulp.
TLDR
The results establish the presence of presynaptic beta-adrenoceptors on sympathetic nerves in human dental pulp and it is suggested that they are of the beta2-subtype, although a greater range of agonists and antagonists needs to be used to clarify the nature of the the beta- adrenoceptor subtype. Expand
Uptake and release of [3H]GABA in human dental pulp
Abstract The purpose of this study was to determine whether (a) an uptake system for γ-aminobutyric acid (GABA) exists in human dental pulp, (b) GABA can be released from nerves in this tissue, andExpand
Uptake and release of [(3)H]GABA in human dental pulp.
TLDR
GA can be taken up and bound firmly in compartments within human dental pulp, GABA can be released from isolated pulp segments by electrical stimulation, and this release is modulated by GABA(B) autoreceptors. Expand
GABAergic modulation of noradrenaline release in the median preoptic nucleus area in the rat
TLDR
Results show the participation of both GABA(A) and GABA(B) receptors in the modulation of the release of NA in the MnPO area, and imply that the GABA( A) receptor mechanism may play an important role in the noradrenergic regulatory system of body fluid balance. Expand
Bicuculline-insensitive GABA receptors on peripheral autonomic nerve terminals.
TLDR
Data suggest the presence of a bicuculline-insensitive GABA receptor on autonomic nerve terminals, and preliminary observations indicate a lack of chloride ion dependence in the action of GABA at this site. Expand
The morpholino-acetic acid analogue Sch 50911 is a selective GABA(B) receptor antagonist in rat neocortical slices.
TLDR
Sch 50911 is a relatively potent antagonist of considerable potential in studies of GABA(B) receptor function, and in slices preloaded with [3H]GABA, Sch 50911 antagonised GABA( B) autoreceptors, increasing the electrically-stimulated 3H overflow in a concentration-dependent manner. Expand
...
1
2
3
...