GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence.

@article{Soyka2008GABAA2RS,
  title={GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence.},
  author={Michael Soyka and Ulrich W. Preuss and Victor M. Hesselbrock and Peter Zill and G. Koller and Brigitta Bondy},
  journal={Journal of psychiatric research},
  year={2008},
  volume={42 3},
  pages={184-91}
}
Gamma-aminobutyric acid (GABA) A receptors are believed to mediate some of the physiological and behavioral actions of ethanol. Recent studies have suggested that genetic variants of the GABA-A receptor alpha2 subunit gene (GABRA2) are associated with alcohol dependence. The aim of this study is to confirm and extend the role of GABRA2 haplotypes in the liability to alcohol dependence. 291 (231 male) treatment-seeking alcohol-dependent individuals and 295 (153 male) control subjects were… CONTINUE READING