GABA(B) receptor modulation of serotonin neurons in the dorsal raphé nucleus and escalation of aggression in mice.

@article{Takahashi2010GABABRM,
  title={GABA(B) receptor modulation of serotonin neurons in the dorsal raph{\'e} nucleus and escalation of aggression in mice.},
  author={Aki Takahashi and Akiko Shimamoto and Christopher O. Boyson and Joseph F. Debold and Klaus A Miczek},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 35},
  pages={
          11771-80
        }
}
The serotonin (5-HT) system in the brain has been studied more than any other neurotransmitter for its role in the neurobiological basis of aggression. However, which mechanisms modulate the 5-HT system to promote escalated aggression is not clear. We here explore the role of GABAergic modulation in the raphé nuclei, from which most 5-HT in the forebrain originates, on escalated aggression in male mice. Pharmacological activation of GABA(B), but not GABA(A), receptors in the dorsal raph… CONTINUE READING

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