GABA(B)-receptor mediation of the inhibitory effect of gamma-hydroxybutyric acid on intestinal motility in mice.

Abstract

The effect of acutely administered gamma-hydroxybutyric acid (GHB) and GHB receptor antagonist, NCS-382, on the propulsive activity in the mouse small intestine was assessed by measuring the transit of an orally administered, non absorbable marker. Both GHB (0, 25, 50, 100, 200 and 300 mg/kg; i.p.) and NCS-382 (0, 25, 50 and 75 mg/kg; i.p.) induced a dose… (More)

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@article{Carai2002GABABreceptorMO, title={GABA(B)-receptor mediation of the inhibitory effect of gamma-hydroxybutyric acid on intestinal motility in mice.}, author={Mauro A. M. Carai and R Agabio and Carla Lobina and Roberta Reali and Giovanni Vacca and G. Colombo and Gian Luigi Gessa}, journal={Life sciences}, year={2002}, volume={70 25}, pages={3059-67} }