GABA‐Benzodiazepine‐Barbiturate Receptor Interactions

@article{Olsen1981GABABenzodiazepineBarbiturateRI,
  title={GABA‐Benzodiazepine‐Barbiturate Receptor Interactions},
  author={R. Olsen},
  journal={Journal of Neurochemistry},
  year={1981},
  volume={37}
}
  • R. Olsen
  • Published 1981
  • Chemistry, Medicine
  • Journal of Neurochemistry
The major inhibitory neurotransmitter in mammalian brain, y-aminobutyric acid (GABA), exerts its effects through increased postsynaptic membrane permeability to chloride ions (McBurney and Barker, 1978; Nistri et a]., 1980). The GABA receptor and associated chloride ion channel appear to be part of a protein complex containing receptor sites for GABA, benzodiazepines, and picrotoxininl barbiturates, as well as the chloride ionophore (Fig. 1). The three types of drug receptor sites studied by… Expand
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