GABA: an excitatory transmitter in early postnatal life

@article{Cherubini1991GABAAE,
  title={GABA: an excitatory transmitter in early postnatal life},
  author={Enrico Cherubini and Jean-Luc Gaiarsa and Yehezkel Ben-Ari},
  journal={Trends in Neurosciences},
  year={1991},
  volume={14},
  pages={515-519}
}
In the adult mammalian CNS, GABA is the main inhibitory transmitter. It inhibits neuronal firing by increasing a Cl- conductance. Bicuculline blocks this effect and induces interictal discharges. A different picture is present in neonatal hippocampal neurones, where synaptically released or exogenously applied GABA depolarizes and excites neuronal membranes--an effect that is due to a different Cl- gradient. In fact, during the early neonatal period, GABA acting on GABAA receptors provides most… Expand
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