GABA(C) receptors as drug targets.

  title={GABA(C) receptors as drug targets.},
  author={Graham A. R. Johnston and Mary Chebib and Jane R. Hanrahan and Kenneth N. Mewett},
  journal={Current drug targets. CNS and neurological disorders},
  volume={2 4},
GABA(C) receptors are the least studied of the three major classes of GABA receptors. The physiological roles of GABA(C) receptors are still being unravelled and the pharmacology of these receptors is being developed. A range of agents has been described that act on GABA(C) receptors with varying degrees of specificity as agonists, partial agonists, antagonists and allosteric modulators. Pharmacological differences are known to exist between subtypes of cloned GABA(C) receptors that have been… CONTINUE READING