GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer.

@article{Robbins2001GABAB2IE,
  title={GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer.},
  author={Melanie J. Robbins and Andrew R. Calver and Alexander K. Filippov and Warren D. Hirst and Robert B. Russell and Michelle D Wood and Shabina Nasir and Andr{\'e}s Couve and Deborah A. Brown and Stephen J. Moss and Menelas N. Pangalos},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 20},
  pages={8043-52}
}
GABA(B) receptors are unique among G-protein-coupled receptors (GPCRs) in their requirement for heterodimerization between two homologous subunits, GABA(B1) and GABA(B2), for functional expression. Whereas GABA(B1) is capable of binding receptor agonists and antagonists, the role of each GABA(B) subunit in receptor signaling is unknown. Here we identified amino acid residues within the second intracellular domain of GABA(B2) that are critical for the coupling of GABA(B) receptor heterodimers to… CONTINUE READING
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