GABA(B) receptors couple directly to the transcription factor ATF4.

  title={GABA(B) receptors couple directly to the transcription factor ATF4.},
  author={Ellen G. Vernon and Gundela Meyer and Lisa Pickard and Kapil Dev and Elek Moln{\'a}r and Graham L Collingridge and Jeremy M Henley},
  journal={Molecular and cellular neurosciences},
  volume={17 4},
The inhibitory neurotransmitter gamma-aminobutyric acid (GABA), acts at ionotropic (GABA(A) and GABA(C)) and metabotropic (GABA(B)) receptors. Functional GABA(B) receptors are heterodimers of GABA(B(1)) and GABA(B(2)) subunits. Here we show a robust, direct, and specific interaction between the coiled-coil domain present in the C-terminus of the GABA(B(1)) subunit and the transcription factor ATF4 (also known as CREB2). ATF4 and GABA(B(2)) binding to the GABA(B(1)) subunit were mutually… CONTINUE READING


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