GABA(B) receptor-mediated increase of neurosteroids by gamma-hydroxybutyric acid.

@article{Barbaccia2002GABABRI,
  title={GABA(B) receptor-mediated increase of neurosteroids by gamma-hydroxybutyric acid.},
  author={Maria Luisa Barbaccia and Giancarlo Colombo and Daniela Affricano and Mauro A. M. Carai and Giovanni Vacca and Samuele Melis and Robert H. Purdy and Gian Luigi Gessa},
  journal={Neuropharmacology},
  year={2002},
  volume={42 6},
  pages={782-91}
}
Among the pharmacological actions of gamma-hydroxybutyric acid (GHB), some may involve GABA(A) receptor-mediated mechanisms. GHB, however, fails to directly interact with sites for agonists and modulators on the GABA(A) receptor complex. We hypothesized that, in vivo, GHB may interfere with GABA(A) receptor function by altering the brain concentrations of the neurosteroids 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone, AP) and 3 alpha,21-dihydroxy-5 alpha-pregnan-20-one… CONTINUE READING