GABA(A) receptors and alcohol.

  title={GABA(A) receptors and alcohol.},
  author={Ingrid A Lobo and R. Adron Harris},
  journal={Pharmacology, biochemistry, and behavior},
  volume={90 1},
There is substantial evidence that GABAergic neurotransmission is important for many behavioral actions of ethanol and there are reports spanning more than 30 years of literature showing that low to moderate (3-30 mM) concentrations of ethanol enhance GABAergic neurotransmission. A key question is which GABA receptor subunits are sensitive to low concentrations of ethanol in vivo and in vitro. Recent evidence points to a role for extrasynaptic receptors. Another question is which behavioral… CONTINUE READING
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