GABA(A) receptor subunits in the rat hippocampus II: altered distribution in kainic acid-induced temporal lobe epilepsy.

@article{Schwarzer1997GABAARS,
  title={GABA(A) receptor subunits in the rat hippocampus II: altered distribution in kainic acid-induced temporal lobe epilepsy.},
  author={Christoph Schwarzer and Koichi Tsunashima and C Wanzenb{\"o}ck and Kristine Fuchs and Werner Sieghart and G{\"u}nther Sperk},
  journal={Neuroscience},
  year={1997},
  volume={80 4},
  pages={1001-17}
}
Intraperitoneal injection of kainic acid in the rat represents a widely used animal model of human temporal lobe epilepsy. Injection of kainic acid induces acute limbic seizures which are accompanied by seizure-induced brain damage and late spontaneous recurrent seizures. There is considerable evidence for an altered transmission of GABA in human temporal lobe epilepsy and in the kainic acid model. We therefore investigated by immunocytochemistry the distribution of 13 GABA receptor subunits in… CONTINUE READING

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