GABA(A) receptor epsilon-subunit may confer benzodiazepine insensitivity to the caudal aspect of the nucleus tractus solitarii of the rat.

@article{Kasparov2001GABAARE,
  title={GABA(A) receptor epsilon-subunit may confer benzodiazepine insensitivity to the caudal aspect of the nucleus tractus solitarii of the rat.},
  author={Sergey Kasparov and Kevin A. Davies and Upasana A Patel and Pedro L Boscan and Maurice Garret and Julian Paton},
  journal={The Journal of physiology},
  year={2001},
  volume={536 Pt 3},
  pages={785-96}
}
1. Benzodiazepines (BZ) and barbiturates both potentiate chloride currents through GABA(A) receptors to enhance inhibition. However, unlike barbiturates BZ do not impair autonomic control of heart rate. We hypothesised that BZ might not significantly potentiate GABAergic transmission in the caudal nucleus of the solitary tract (cNTS), which is critically important for mediating the baroreceptor reflex. 2. In rat brain slices the BZ agonists chlordiazepoxide and midazolam (2 and 50 microM) did… CONTINUE READING

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