GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers.

  title={GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers.},
  author={Eric M. Reiman and Jennifer A. Webster and Amanda J. Myers and John S. Hardy and Travis Dunckley and Victoria Zismann and Keta Joshipura and John V. Pearson and Diane Hu-Lince and Matthew J. Huentelman and David W. Craig and Keith D. Coon and Winnie S. Liang and RiLee H. Herbert and Thomas Gerald Beach and Kristen C. Rohrer and Alice S. Zhao and Doris Leung and Leslie A Bryden and Lauren E Marlowe and Mona M Kaleem and Diego Mastroeni and Andrew Grover and Christopher B. Heward and Rivka G. Ravid and Joseph Rogers and Michael L. Hutton and Stacey Melquist and Ron C. Petersen and Gene E. Alexander and Richard J. Caselli and Walter B Kukull and Andreas Papassotiropoulos and Dietrich A. Stephan},
  volume={54 5},
The apolipoprotein E (APOE) epsilon4 allele is the best established genetic risk factor for late-onset Alzheimer's disease (LOAD). We conducted genome-wide surveys of 502,627 single-nucleotide polymorphisms (SNPs) to characterize and confirm other LOAD susceptibility genes. In epsilon4 carriers from neuropathologically verified discovery, neuropathologically verified replication, and clinically characterized replication cohorts of 1411 cases and controls, LOAD was associated with six SNPs from… CONTINUE READING
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