G9a regulates temporal preimplantation developmental program and lineage segregation in blastocyst

@inproceedings{Zylicz2018G9aRT,
  title={G9a regulates temporal preimplantation developmental program and lineage segregation in blastocyst},
  author={Jan J Zylicz and Maud Borensztein and Frederick Ck Wong and Yun Huang and Caroline LG Lee and Sabine Dietmann and M Azim Surani},
  booktitle={eLife},
  year={2018}
}
Early mouse development is regulated and accompanied by dynamic changes in chromatin modifications, including G9a-mediated histone H3 lysine 9 dimethylation (H3K9me2). Previously, we provided insights into its role in post-implantation development (Zylicz et al., 2015). Here we explore the impact of depleting the maternally inherited G9a in oocytes on… CONTINUE READING