G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta.

@article{Pless2008G9amediatedLM,
  title={G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta.},
  author={Ole Pless and Elisabeth Kowenz-Leutz and Maria Knoblich and J{\"o}rn Lausen and Michael Beyermann and Martin J. Walsh and Achim Leutz},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 39},
  pages={26357-63}
}
The functional capacity of the transcriptional regulatory CCAAT/enhancer-binding protein-beta (C/EBPbeta) is governed by protein interactions and post-translational protein modifications. In a proteome-wide interaction screen, the histone-lysine N-methyltransferase, H3 lysine 9-specific 3 (G9a), was found to directly interact with the C/EBPbeta transactivation domain (TAD). Binding between G9a and C/EBPbeta was confirmed by glutathione S-transferase pulldown and co-immunoprecipitation… CONTINUE READING