G9a and HP1 couple histone and DNA methylation to TNFalpha transcription silencing during endotoxin tolerance.

@article{Gazzar2008G9aAH,
  title={G9a and HP1 couple histone and DNA methylation to TNFalpha transcription silencing during endotoxin tolerance.},
  author={Mohamed El Gazzar and Barbara K Yoza and Xiaoping Chen and Jean Y-Q Hu and Gregory A Hawkins and Charles E McCall},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 47},
  pages={32198-208}
}
TNFalpha gene expression is silenced in the endotoxin tolerant phenotype that develops in blood leukocytes after the initial activation phase of severe systemic inflammation or sepsis. The silencing phase can be mimicked in vitro by LPS stimulation. We reported that the TNFalpha transcription is disrupted in endotoxin tolerant THP-1 human promonocyte due to changes in transcription factor binding and enrichment with histone H3 dimethylated on lysine 9 (H3K9). Here we show that the TNFalpha… CONTINUE READING

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