G551D CF mice display an abnormal host response and have impaired clearance of Pseudomonas lung disease.

@article{McMorran2001G551DCM,
  title={G551D CF mice display an abnormal host response and have impaired clearance of Pseudomonas lung disease.},
  author={B J McMorran and J S Palmer and D P Lunn and D Oceandy and Elaine O Costelloe and G R Thomas and D A Hume and Brandon J. Wainwright},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2001},
  volume={281 3},
  pages={L740-7}
}
  • B J McMorran, J S Palmer, +5 authors Brandon J. Wainwright
  • Published 2001 in
    American journal of physiology. Lung cellular and…
Several cystic fibrosis (CF) mouse models demonstrate an increased susceptibility to Pseudomonas aeruginosa lung infection, characterized by excessive inflammation and high rates of mortality. Here we developed a model of chronic P. aeruginosa lung disease in mice homozygous for the murine CF transmembrane conductance regulator G551D mutation that provides an excellent model for CF lung disease. After 3 days of infection with mucoid P. aeruginosa entrapped in agar beads, the G551D animals lost… CONTINUE READING
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Pseudomonas Lung Disease in G551d Cf Mice

  • WH Colledge, BS Abella, +6 authors AW Cuthbert
  • AJP-Lung Cell Mol Physiol
  • 2001
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