G5-PEG PAMAM dendrimer incorporating nanostructured lipid carriers enhance oral bioavailability and plasma lipid-lowering effect of probucol.

@article{Qi2015G5PEGPD,
  title={G5-PEG PAMAM dendrimer incorporating nanostructured lipid carriers enhance oral bioavailability and plasma lipid-lowering effect of probucol.},
  author={Rong Qi and Yan-zhi Li and Cong Chen and Yi-Ni Cao and Mao-Mao Yu and Lu Xu and Bing He and Xu Hou Jie and Wen-wen Shen and Yu-nan Wang and Mallory van Dongen and Guo-qing Liu and Mark M Banaszak Holl and Qiang Zhang and Xue Dan Ke},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2015},
  volume={210},
  pages={160-8}
}
This work aimed to improve the oral bioavailability and plasma lipid-lowering effect of probucol (PB) by constructing a combined drug delivery system (CDDS) composed of nanostructured lipid carrier (NLC) and PEGylated poly(amidoamine) dendrimer (PEG-PAMAM). PEG-PAMAM with dendrimer generations of 5 (G5-PEG) or 7 (G7-PEG) were incorporated in PB-NLCs to form PB-CDDSs, PB-NLCs/G5-PEG and PB-NLCs/G7-PEG. The resultant two kinds of PB-CDDSs were characterized by particle size, zeta potential, drug… CONTINUE READING
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