G4 motifs affect origin positioning and efficiency in two vertebrate replicators.

@article{Valton2014G4MA,
  title={G4 motifs affect origin positioning and efficiency in two vertebrate replicators.},
  author={Anne-Laure Valton and Vahideh Hassan-Zadeh and Ingrid Lema and Nicole Boggetto and Patrizia Alberti and Carole Saintom{\'e} and Jean-François Riou and M N Prioleau},
  journal={The EMBO journal},
  year={2014},
  volume={33 7},
  pages={
          732-46
        }
}
DNA replication ensures the accurate duplication of the genome at each cell cycle. It begins at specific sites called replication origins. Genome-wide studies in vertebrates have recently identified a consensus G-rich motif potentially able to form G-quadruplexes (G4) in most replication origins. However, there is no experimental evidence to demonstrate that G4 are actually required for replication initiation. We show here, with two model origins, that G4 motifs are required for replication… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 65 CITATIONS, ESTIMATED 85% COVERAGE

FILTER CITATIONS BY YEAR

2014
2019

CITATION STATISTICS

  • 4 Highly Influenced Citations

  • Averaged 7 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

FANCJ: solving problems in DNA replication.

  • DNA repair
  • 2010
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL