G20210A mutation in prothrombin gene and risk of myocardial infarction, stroke, and venous thrombosis in a large cohort of US men.

@article{Ridker1999G20210AMI,
  title={G20210A mutation in prothrombin gene and risk of myocardial infarction, stroke, and venous thrombosis in a large cohort of US men.},
  author={Paul M. Ridker and Charles H. Hennekens and Joseph P. Miletich},
  journal={Circulation},
  year={1999},
  volume={99 8},
  pages={999-1004}
}
BACKGROUND A single base pair mutation in the prothrombin gene has recently been identified that is associated with increased prothrombin levels. Whether this mutation increases the risks of arterial and venous thrombosis among healthy individuals is controversial. METHODS AND RESULTS In a prospective cohort of 14 916 men, we determined the prevalence of the G20210A prothrombin gene variant in 833 men who subsequently developed myocardial infarction, stroke, or venous thrombosis (cases) and… CONTINUE READING

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The prevalence of the 20210 G-A mutation in the 3 9-untranslated region of the prothrombin gene in patients with premature coronary artery disease.Thromb Haemost. 1997;78:769

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