G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain.

@article{Nguyen2018G2019SLE,
  title={G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain.},
  author={An Phu Tran Nguyen and Guillaume Daniel and Pamela Vald{\'e}s and Md Shariful Islam and Bernard L Schneider and Darren Moore},
  journal={Human molecular genetics},
  year={2018},
  volume={27 1},
  pages={120-134}
}
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant Parkinson's disease (PD). LRRK2 mutations typically give rise to Lewy pathology in the brains of PD subjects yet can induce tau-positive neuropathology in some cases. The pathological interaction between LRRK2 and tau remains poorly defined. To explore this… CONTINUE READING