G2-checkpoint abrogation in irradiated lymphocytes: A new cytogenetic approach to assess individual radiosensitivity and predisposition to cancer.

@article{Terzoudi2009G2checkpointAI,
  title={G2-checkpoint abrogation in irradiated lymphocytes: A new cytogenetic approach to assess individual radiosensitivity and predisposition to cancer.},
  author={Georgia I. Terzoudi and Vasiliki I. Hatzi and Katarzyna Barszczewska and Kalliopi N. Manola and Chryssa Stavropoulou and Philip Angelakis and Gabriel E. Pantelias},
  journal={International journal of oncology},
  year={2009},
  volume={35 5},
  pages={1223-30}
}
Increased yield of chromatid breaks, following in vitro G2-phase lymphocyte irradiation, can be a marker of individual radiosensitivity and cancer predisposing genes whose role is to respond to DNA damage. Mutations or polymorphisms of genes encoding DNA repair pathways may underlie the increased chromosomal radiosensitivity. However, genes that facilitate DNA damage recognition, using signal transduction pathways to activate cell cycle arrest and preserve genomic integrity, are perhaps the… CONTINUE READING

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