G16R single nucleotide polymorphism but not haplotypes of the β(2)-adrenergic receptor gene alters cardiac output in humans.

@article{Rokamp2013G16RSN,
  title={G16R single nucleotide polymorphism but not haplotypes of the β(2)-adrenergic receptor gene alters cardiac output in humans.},
  author={Kim Zillo Rokamp and Jonatan M Staalsoe and Martin Gartmann and Anna Sletgaard and Nicolai B Nordsborg and Niels H Secher and H B Nielsen and Niels Vidiendal Olsen},
  journal={Clinical science},
  year={2013},
  volume={125 4},
  pages={191-8}
}
Variation in genes encoding the β(2)-adrenergic receptor (ADRB2) and angiotensin-converting enzyme (ACE) may influence Q (cardiac output). The 46G>A (G16R) SNP (single nucleotide polymorphism) has been associated with β(2)-mediated vasodilation, but the effect of ADRB2 haplotypes on Q has not been studied. Five SNPs within ADRB2 (46G>A, 79C>G, 491C>T, 523C>A and 1053G>C by a pairwise tagging principle) and the I/D (insertion/deletion) polymorphism in ACE were genotyped in 143 subjects… CONTINUE READING
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