G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast.

@article{Barral1995G1CT,
  title={G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast.},
  author={Y Barral and Stefan Jentsch and Carl L A Mann},
  journal={Genes & development},
  year={1995},
  volume={9 4},
  pages={399-409}
}
Entry into a new cell cycle is triggered by environmental signals at a point called Start in G1 phase. A key regulator of this transition step in yeast is the CDC28 kinase together with its short-lived regulatory subunits called G1-cyclins or CLN proteins. To identify genes involved in G1-cyclin degradation, we employed a genetic screen by selecting for stable CLN1-beta-galactosidase fusion proteins. Surprisingly, one group of mutants was found to be allelic to GRR1, a gene previously described… CONTINUE READING
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