G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments.


Angiogenin (ANG) is a stress-activated ribonuclease that promotes the survival of motor neurons. Ribonuclease inactivating point mutations are found in a subset of patients with ALS, a fatal neurodegenerative disease with no cure. We recently showed that ANG cleaves tRNA within anticodon loops to produce 5'- and 3'-fragments known as tRNA-derived, stress… (More)
DOI: 10.1073/pnas.1407361111


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