G-quadruplex-interacting compounds alter latent DNA replication and episomal persistence of KSHV

@inproceedings{Madireddy2016GquadruplexinteractingCA,
  title={G-quadruplex-interacting compounds alter latent DNA replication and episomal persistence of KSHV},
  author={Advaitha Madireddy and Pravinkumar Purushothaman and Christopher P. Loosbroock and Erle S Robertson and C. L. Schildkraut and Subhash C Verma},
  booktitle={Nucleic acids research},
  year={2016}
}
Kaposi's sarcoma associated herpesvirus (KSHV) establishes life-long latent infection by persisting as an extra-chromosomal episome in the infected cells and by maintaining its genome in dividing cells. KSHV achieves this by tethering its epigenome to the host chromosome by latency associated nuclear antigen (LANA), which binds in the terminal repeat (TR) region of the viral genome. Sequence analysis of the TR, a GC-rich DNA element, identified several potential Quadruplex G-Rich Sequences… CONTINUE READING
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