G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription

  title={G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription},
  author={Susanna Cogoi and Luigi E Xodo},
  journal={Nucleic Acids Research},
  pages={2536 - 2549}
In human and mouse, the promoter of the KRAS gene contains a nuclease hypersensitive polypurine-polypyrimidine element (NHPPE) that is essential for transcription. An interesting feature of the polypurine G-rich strand of NHPPE is its ability to assume an unusual DNA structure that, according to circular dichroism (CD) and DMS footprinting experiments, is attributed to an intramolecular parallel G-quadruplex, consisting of three G-tetrads and three loops. The human and mouse KRAS NHPPE G-rich… CONTINUE READING
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