G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding.

  title={G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding.},
  author={Sujay Ray and Jigar N. Bandaria and Mohammad Haroon Qureshi and Ahmet Yildiz and Hamza Balci},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 8},
Human telomeres terminate with a single-stranded 3' G overhang, which can be recognized as a DNA damage site by replication protein A (RPA). The protection of telomeres (POT1)/POT1-interacting protein 1 (TPP1) heterodimer binds specifically to single-stranded telomeric DNA (ssTEL) and protects G overhangs against RPA binding. The G overhang spontaneously folds into various G-quadruplex (GQ) conformations. It remains unclear whether GQ formation affects the ability of POT1/TPP1 to compete… CONTINUE READING

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