G-quadruplex conformation and dynamics are determined by loop length and sequence

@inproceedings{Tippana2014GquadruplexCA,
  title={G-quadruplex conformation and dynamics are determined by loop length and sequence},
  author={Ramreddy Tippana and Weikun Xiao and Sua Myong},
  booktitle={Nucleic acids research},
  year={2014}
}
The quadruplex forming G-rich sequences are unevenly distributed throughout the human genome. Their enrichment in oncogenic promoters and telomeres has generated interest in targeting G-quadruplex (GQ) for an anticancer therapy. Here, we present a quantitative analysis on the conformations and dynamics of GQ forming sequences measured by single molecule fluorescence. Additionally, we relate these properties to GQ targeting ligands and G4 resolvase 1 (G4R1) protein binding. Our result shows that… CONTINUE READING

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