G-quadruplex DNA recognition by nucleophosmin: new insights from protein dissection.

  title={G-quadruplex DNA recognition by nucleophosmin: new insights from protein dissection.},
  author={Pasqualina Liana Scognamiglio and Concetta Di Natale and Michael R. Leone and Mattia Poletto and Luigi Vitagliano and Gianluca Tell and Daniela Marasco},
  journal={Biochimica et biophysica acta},
  volume={1840 6},
BACKGROUND Nucleophosmin (NPM1, B23) is a multifunctional protein that is involved in a variety of fundamental biological processes. NPM1/B23 deregulation is implicated in the pathogenesis of several human malignancies. This protein exerts its functions through the interaction with a multiplicity of biological partners. Very recently it is has been shown that NPM1/B23 specifically recognizes DNA G-quadruplexes through its C-terminal region. METHODS Through a rational dissection approach of… CONTINUE READING

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